06 January 2010

The History of Disconnections

Curly Arrow blog writes about the history of curly arrows explaining that they were the idea of Robert Robinson.

Something else invented by Robinson was the disconnection approach made famous by Stuart Warren's book of the same name.

The disconnection approach is an intellectual strategy designed to help chemists design a synthesis of a molecule. An approach that I've used many many times in order to synthesise new molecules. Astounding to think that Robinson published these ideas almost one hundred years ago (1917 sadly, pay per view) and called his disconnections, imaginary hydrolysis.

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