09 October 2009
Next Health Fad - Essence of Celery
(S)-(−)-3-n-butylphthalide is found in celery seeds and is thought to be beneficial to ones health.
Twelve or so hours ago my feed reported to me a synthesis that allows for the preparation of this compound.
In the abstract (DOI: 10.1021/ja907711a) the author says,
"Herein we communicate the first atom-economical approach to phthalides by using enantioselective ketone hydroacylation."
So, not only talented scientists but witty, "atom-economical"; err, would it be possible to design a synthesis that is any more atom-economical?
In short, a cheap clean synthesis of a compound that is most probably very easy to scale up with a potential market awaiting it.
All very impressive.
For a mechanistic insight check out doi: 10.1021/ja806758m whilst not exactly the same platform as the above chemistry one can easily extrapolate from what is given in the paper.
Other examples from another group (DOI: 10.1039/b912850f):