24 May 2009

One That Got Away

The Serious Organised Crime Agency has a facility where one can report Chemical Suspicious Activity; they seem to be hoping to catch people who misuse chemicals by preparing drugs, explosives or other nefarious things.

Curiously, I don't see the following compound on their list of banned substances ...

... so, what's so special about the above compound?

Well, it is part of an unpublished (until now) route to amphetamines.

Dissolving the compound in an anhydrous, aprotic solvent, adding a reasonably strong base, and quenching with acetic anhydride (or, some say, ethyl acetate) gives the following intermediate.

The cognoscenti should be able to see the next steps as hydrolysis and decarboxylation to give one of the compounds that is on the banned list.

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